Synthesis and antimicrobial evaluation of 2-(2-butyl- 4-chloro-1H-imidazol-5-yl-methylene)-substituted-benzofuran-3-ones
Bhaskar S. Dawane, Shankaraiah G. Konda, Namdev T. Khandare, Santosh S. Chobe, Baseer M. Shaikh, Ragini G. Bodade and Vishwas D. Joshi
Org. Commun. (2010), 3:2 ; 22-29
Organic Research Laboratory, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded 431602, India
Swami Ramanand Teerth Marathawada University, School of Life Sciences, Nanded 431606, India
Abstract: In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1H-imidazol-5-yl)methylene)benzofuran-3(2H)-ones. Newly synthesized compounds were tested for their in vitro antimicrobial activity.
Keywords: PEG-400; 2’-hydroxy chalcones; benzofuran-3-ones; antimicrobial activity. |